A total of 43 (30.9%) patients were diagnosed with radiation necrosis. The mean ± standard deviation (SD) for age was 60.4 ± 13.6 years, female:male ratio was 71:68, and White:African American:other race ratio was 112:24:3.

ResultsĪ total of 139 patients were studied. ROC curves were used to evaluate the performance of prediction or discrimination of the logistic regression models. Finally, adjusted and unadjusted logistic regression models were used to predict radiation necrosis using a single risk factor or multiple risk factors. These candidate risk factors were further used to assess their associations to demographics and other characteristics of cancer and treatments. Statistical association analyses were used to identify candidate risk factors to radiation necrosis. Cases that did not have an MRI available at least two months after the completion of RT were excluded. The diagnosis of radiation necrosis was based on MRI reports that were examined for a time period of 24 months following the completion of radiation treatment and confirmed, when possible, by biopsy. Total RT dose, fraction size, volume of brain receiving 12 Gy (V12), and retreatment of locally recurrent tumors were recorded from Eclipse. Data regarding demographics, characteristics of cancer, chemotherapy status and class, comorbidities, and additional medications of patients were collected via EPIC. MethodsĪ retrospective chart review was performed on patients who were diagnosed with brain tumors and received RT (3D conformal therapy, volumetric modulated arc therapy, stereotactic radiosurgery, or stereotactic radiotherapy) at the University of Arkansas for Medical Sciences from July 1, 2017, to July 1, 2019.

The goal of this study is to identify risk factors for cerebral radiation necrosis in order to improve clinicians’ ability to appropriately weigh the risks and benefits of brain RT. Currently, risk factors for radiation necrosis are not well characterized. These symptoms may be progressive and treatment-resistant. Radiation necrosis in the brain is a frequent complication of brain radiation therapy (RT) and is characterized by various neurological symptoms including cognitive dysfunction, headaches, weakness, apraxia, aphasia, and numbness.

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